Interview with Dr Florence Laigle-Donadey about the fiSurgery versus Biopsy for Potentially Operable GBM in the Elderlyfl trial
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Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas.
The O(6)-methylguanine-DNA methyltransferase gene (MGMT) is methylated in several cancers, including gliomas. However, the functional role of cysteine-phosphate-guanine (CpG) island (CGI) methylation in MGMT silencing is still controversial. The aim of this study was to investigate whether MGMT CGI methylation correlates inversely with RNA expression of MGMT in glioblastomas and to determine th...
متن کاملEORTC 26083 phase I/II trial of dasatinib in combination with CCNU in patients with recurrent glioblastoma.
The treatment of patients with recurrent glioblastoma remains a major oncologic problem, with median survival after progression of 7-9 months. To determine the maximum tolerated dose and dose-limiting toxicity (DLT), the combination of dasatinib and cyclonexyl-chloroethyl-nitrosourea (CCNU) was investigated in this setting. The study was designed as multicenter, randomized phase II trial, prece...
متن کاملChromosome 9p and 10q losses predict unfavorable outcome in low-grade gliomas.
The loss of chromosomes 1p-19q is the only prognostic molecular alteration identified in low-grade gliomas (LGGs) to date. Search for loss of heterozygosity (LOH) on chromosomes 1p, 9p, 10q, and 19q was performed in a series of 231 LGGs. Loss of chromosomes 1p-19q was strongly correlated with prolonged progression-free survival (PFS) and overall survival (OS) in univariate and multivariate anal...
متن کاملGene amplification is a poor prognostic factor in anaplastic oligodendrogliomas.
Various gene amplifications have been observed in gliomas. Prognostic-genomic correlations testing simultaneously all these amplified genes have never been conducted in anaplastic oligodendrogliomas. A set of 38 genes that have been reported to be amplified in gliomas and investigated as the main targets of amplicons were studied in a series of 52 anaplastic oligodendrogliomas using bacterial a...
متن کاملJALDA's Interview with Dr. Farshid Sadatsharifi
Farshid Sadatsharifi has been visiting scholar at the Institute of Islamic Studies in McGill University, Montreal, Canada since 2016. He received his PhD and MA in Persian Language and Literature from Shiraz University, Iran. He also completed his post-doc fellowship in Interdisciplinary Approaches to Literature at the same university. Dr. Sadatsharifi is the co-founder and director of Samaak I...
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تاریخ انتشار 2016